Since before time itself, during the cataclysm that ended the previous universe and in which this one was born, the Order of Alchemy has persisted. It is unknown just when or who the creator was.
Always present in the backgrounds, alchemists have been involved in science, religion and politics since civilization developed after the end of the Great Game. 1)
Their main involvement in Improbable Island takes the form of the Count of Saint Germain. The presence of other alchemists who take a less prominent role has been hinted at during discussions with the Count. After all, the Count's decision to be a prominent member of the community is rather abnormal for an alchemist. 2)